The core gut microbiome, energy balance and obesity.

TitleThe core gut microbiome, energy balance and obesity.
Publication TypeJournal Article
Year of Publication2009
AuthorsTurnbaugh, PJ, Gordon, JI
JournalJ Physiol
IssuePt 17
Date Published2009 Sep 1
KeywordsAnimals, Energy Metabolism, Humans, Intestines, Metagenome, Models, Biological, Obesity

Metagenomics is an emerging field focused on characterizing the structures, functions and dynamic operations of microbial communities sampled in their native habitats without the need for culture. Here, we present findings from a 16S rRNA gene sequence- and whole community DNA shotgun sequencing-based analysis of the adult human gut microbiomes of lean and obese mono- and dizygotic twins. Our findings indicate that a core microbiome can be found at the gene level, despite large variation in community membership, and that variations from the core are associated with obesity. These findings have implications for ongoing Human Microbiome Project(s), and highlight important challenges to the field of metagenomics.

Alternate JournalJ. Physiol. (Lond.)
PubMed ID19491241
PubMed Central IDPMC2754355
Grant ListDK078669 / DK / NIDDK NIH HHS / United States
DK70977 / DK / NIDDK NIH HHS / United States
UL1 RR024992 / RR / NCRR NIH HHS / United States