Evolution of mammals and their gut microbes.

TitleEvolution of mammals and their gut microbes.
Publication TypeJournal Article
Year of Publication2008
AuthorsLey, RE, Hamady, M, Lozupone, C, Turnbaugh, PJ, Ramey, RRoy, J Bircher, S, Schlegel, ML, Tucker, TA, Schrenzel, MD, Knight, R, Gordon, JI
JournalScience
Volume320
Issue5883
Pagination1647-51
Date Published2008 Jun 20
ISSN1095-9203
KeywordsAdaptation, Physiological, Animals, Animals, Wild, Animals, Zoo, Bacteria, Bacterial Physiological Phenomena, Biological Evolution, Carnivora, Diet, Feces, Gastrointestinal Tract, Genes, rRNA, Humans, Mammals, Molecular Sequence Data, Phylogeny, Primates, RNA, Ribosomal, 16S
Abstract

Mammals are metagenomic in that they are composed of not only their own gene complements but also those of all of their associated microbes. To understand the coevolution of the mammals and their indigenous microbial communities, we conducted a network-based analysis of bacterial 16S ribosomal RNA gene sequences from the fecal microbiota of humans and 59 other mammalian species living in two zoos and in the wild. The results indicate that host diet and phylogeny both influence bacterial diversity, which increases from carnivory to omnivory to herbivory; that bacterial communities codiversified with their hosts; and that the gut microbiota of humans living a modern life-style is typical of omnivorous primates.

DOI10.1126/science.1155725
Alternate JournalScience
PubMed ID18497261
PubMed Central IDPMC2649005
Grant ListDK30292 / DK / NIDDK NIH HHS / United States
DK70977 / DK / NIDDK NIH HHS / United States
DK78669 / DK / NIDDK NIH HHS / United States
P01 DK078669 / DK / NIDDK NIH HHS / United States
P01 DK078669-02 / DK / NIDDK NIH HHS / United States
R01 DK030292 / DK / NIDDK NIH HHS / United States
R01 DK030292-24 / DK / NIDDK NIH HHS / United States
R01 DK070977 / DK / NIDDK NIH HHS / United States
R01 DK070977-04 / DK / NIDDK NIH HHS / United States
T32 GM065103 / GM / NIGMS NIH HHS / United States
T32 GM065103-07 / GM / NIGMS NIH HHS / United States
T32GM065103 / GM / NIGMS NIH HHS / United States