Host-bacterial coevolution and the search for new drug targets.

TitleHost-bacterial coevolution and the search for new drug targets.
Publication TypeJournal Article
Year of Publication2008
AuthorsZaneveld, J, Turnbaugh, PJ, Lozupone, C, Ley, RE, Hamady, M, Gordon, JI, Knight, R
JournalCurr Opin Chem Biol
Volume12
Issue1
Pagination109-14
Date Published2008 Feb
ISSN1367-5931
KeywordsAnimals, Bacterial Physiological Phenomena, Biological Evolution, Drug Evaluation, Preclinical, Gene Transfer, Horizontal, Host-Pathogen Interactions, Humans, Symbiosis
Abstract

Understanding the coevolution between humans and our microbial symbionts and pathogens requires complementary approaches, ranging from community analysis to in-depth analysis of individual genomes. Here we review the evidence for coevolution between symbionts and their hosts, the role of horizontal gene transfer in coevolution, and genomic and metagenomic approaches to identify drug targets. Recent studies have shown that our symbiotic microbes confer many metabolic capabilities that our mammalian genomes lack, and that targeting mechanisms of horizontal gene transfer is a promising new direction for drug discovery. Gnotobiotic ('germ-free') mice are an especially exciting new tool for unraveling the function of microbes, whether individually or in the context of complex communities.

DOI10.1016/j.cbpa.2008.01.015
Alternate JournalCurr Opin Chem Biol
PubMed ID18280814
PubMed Central IDPMC2348432
Grant ListP01 DK078669 / DK / NIDDK NIH HHS / United States
P01 DK078669-010003 / DK / NIDDK NIH HHS / United States
P01DK078669 / DK / NIDDK NIH HHS / United States
T32 GM08759 / GM / NIGMS NIH HHS / United States
T32GM065103 / GM / NIGMS NIH HHS / United States