Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics.

TitleHost-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics.
Publication TypeJournal Article
Year of Publication2014
AuthorsCarmody, RN, Turnbaugh, PJ
JournalJ Clin Invest
Volume124
Issue10
Pagination4173-81
Date Published2014 Oct
ISSN1558-8238
KeywordsAnimals, Binding Sites, Diet, Gastrointestinal Tract, Gene Expression Regulation, Bacterial, Humans, Intestines, Mice, Mice, Transgenic, Microbial Interactions, Microbiota, Probiotics, Protein Binding, Xenobiotics
Abstract

Our associated microbial communities play a critical role in human health and predisposition to disease, but the degree to which they also shape therapeutic interventions is not well understood. Here, we integrate results from classic and current studies of the direct and indirect impacts of the gut microbiome on the metabolism of therapeutic drugs and diet-derived bioactive compounds. We pay particular attention to microbial influences on host responses to xenobiotics, adding to the growing consensus that treatment outcomes reflect our intimate partnership with the microbial world, and providing an initial framework from which to consider a more comprehensive view of pharmacology and nutrition.

DOI10.1172/JCI72335
Alternate JournalJ. Clin. Invest.
PubMed ID25105361
PubMed Central IDPMC4191041
Grant List1F32DK101154 / DK / NIDDK NIH HHS / United States
P50GM068763 / GM / NIGMS NIH HHS / United States