The intestinal metabolome: an intersection between microbiota and host.

TitleThe intestinal metabolome: an intersection between microbiota and host.
Publication TypeJournal Article
Year of Publication2014
AuthorsUrsell, LK, Haiser, HJ, Van Treuren, W, Garg, N, Reddivari, L, Vanamala, J, Dorrestein, PC, Turnbaugh, PJ, Knight, R
JournalGastroenterology
Volume146
Issue6
Pagination1470-6
Date Published2014 May
ISSN1528-0012
KeywordsAge Factors, Aging, Animals, Bacteria, Humans, Infant, Infant, Newborn, Intestines, Metabolome, Metabolomics, Microbiota, Systems Biology
Abstract

Recent advances that allow us to collect more data on DNA sequences and metabolites have increased our understanding of connections between the intestinal microbiota and metabolites at a whole-systems level. We can also now better study the effects of specific microbes on specific metabolites. Here, we review how the microbiota determines levels of specific metabolites, how the metabolite profile develops in infants, and prospects for assessing a person's physiological state based on their microbes and/or metabolites. Although data acquisition technologies have improved, the computational challenges in integrating data from multiple levels remain formidable; developments in this area will significantly improve our ability to interpret current and future data sets.

DOI10.1053/j.gastro.2014.03.001
Alternate JournalGastroenterology
PubMed ID24631493
PubMed Central IDPMC4102302
Grant ListMFE-112991 / / Canadian Institutes of Health Research / Canada
T32 GM008759 / GM / NIGMS NIH HHS / United States
T32 GM08759 / GM / NIGMS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
/ / Howard Hughes Medical Institute / United States