Is it time for a metagenomic basis of therapeutics?

TitleIs it time for a metagenomic basis of therapeutics?
Publication TypeJournal Article
Year of Publication2012
AuthorsHaiser, HJ, Turnbaugh, PJ
JournalScience
Volume336
Issue6086
Pagination1253-5
Date Published2012 Jun 8
ISSN1095-9203
KeywordsAnimals, Anti-Bacterial Agents, Bacteria, Biotransformation, Drug Therapy, Gastrointestinal Tract, Humans, Metagenome, Metagenomics, Micronutrients, Pharmaceutical Preparations
Abstract

The trillions of microbes associated with the human body are a key part of a comprehensive view of pharmacology. A mechanistic understanding of how the gut microbiota directly and indirectly affects drug metabolism is beginning to emerge.

DOI10.1126/science.1224396
Alternate JournalScience
PubMed ID22674325
Grant ListMFE-112991 / / Canadian Institutes of Health Research / Canada
P50 GM068763 / GM / NIGMS NIH HHS / United States