Marked seasonal variation in the wild mouse gut microbiota.

TitleMarked seasonal variation in the wild mouse gut microbiota.
Publication TypeJournal Article
Year of Publication2015
AuthorsMaurice, CF, Knowles, SCL, Ladau, J, Pollard, KS, Fenton, A, Pedersen, AB, Turnbaugh, PJ
JournalISME J
Volume9
Issue11
Pagination2423-34
Date Published2015 Nov
ISSN1751-7370
Abstract

Recent studies have provided an unprecedented view of the microbial communities colonizing captive mice; yet the host and environmental factors that shape the rodent gut microbiota in their natural habitat remain largely unexplored. Here, we present results from a 2-year 16 S ribosomal RNA gene sequencing-based survey of wild wood mice (Apodemus sylvaticus) in two nearby woodlands. Similar to other mammals, wild mice were colonized by 10 bacterial phyla and dominated by the Firmicutes, Bacteroidetes and Proteobacteria. Within the Firmicutes, the Lactobacillus genus was most abundant. Putative bacterial pathogens were widespread and often abundant members of the wild mouse gut microbiota. Among a suite of extrinsic (environmental) and intrinsic (host-related) factors examined, seasonal changes dominated in driving qualitative and quantitative differences in the gut microbiota. In both years examined, we observed a strong seasonal shift in gut microbial community structure, potentially due to the transition from an insect- to a seed-based diet. This involved decreased levels of Lactobacillus, and increased levels of Alistipes (Bacteroidetes phylum) and Helicobacter. We also detected more subtle but statistically significant associations between the gut microbiota and biogeography, sex, reproductive status and co-colonization with enteric nematodes. These results suggest that environmental factors have a major role in shaping temporal variations in microbial community structure within natural populations.

DOI10.1038/ismej.2015.53
Alternate JournalISME J
PubMed ID26023870
PubMed Central IDPMC4611506
Grant List095831 / / Wellcome Trust / United Kingdom
P50 GM068763 / GM / NIGMS NIH HHS / United States
P50 GM068763 / GM / NIGMS NIH HHS / United States
/ / Intramural NIH HHS / United States