Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology.

TitleMicrobial determinants of biochemical individuality and their impact on toxicology and pharmacology.
Publication TypeJournal Article
Year of Publication2014
AuthorsPatterson, AD, Turnbaugh, PJ
JournalCell Metab
Volume20
Issue5
Pagination761-8
Date Published2014 Nov 4
ISSN1932-7420
KeywordsAnimals, Gastrointestinal Tract, Humans, Microbiota, Pharmaceutical Preparations, Pharmacology, Toxicology, Xenobiotics
Abstract

Humans exhibit remarkable interindividual variations in the concentration of small molecules found throughout the body, due in part to concurrent variations in each person's associated microbial communities. Recent studies have begun to uncover how microbes interface with their host during exposure to drugs, dietary compounds, and environmental toxicants, with broader implications regarding the causes and consequences of biochemical individuality. Progress in this area will likely be an essential component of personalized medicine and might be accelerated through the implementation of experimental designs and theoretical principles honed through decades of work in the fields of toxicology and pharmacology.

DOI10.1016/j.cmet.2014.07.002
Alternate JournalCell Metab.
PubMed ID25156450
PubMed Central IDPMC4252706
Grant ListES022186 / ES / NIEHS NIH HHS / United States
R01 ES022186 / ES / NIEHS NIH HHS / United States