Microbial ecology: human gut microbes associated with obesity.

TitleMicrobial ecology: human gut microbes associated with obesity.
Publication TypeJournal Article
Year of Publication2006
AuthorsLey, RE, Turnbaugh, PJ, Klein, S, Gordon, JI
JournalNature
Volume444
Issue7122
Pagination1022-3
Date Published2006 Dec 21
ISSN1476-4687
KeywordsAdiposity, Animals, Bacteria, Bacteroidetes, Diet, Gastrointestinal Tract, Humans, Obesity, RNA, Ribosomal, 16S
Abstract

Two groups of beneficial bacteria are dominant in the human gut, the Bacteroidetes and the Firmicutes. Here we show that the relative proportion of Bacteroidetes is decreased in obese people by comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet. Our findings indicate that obesity has a microbial component, which might have potential therapeutic implications.

DOI10.1038/4441022a
Alternate JournalNature
PubMed ID17183309
Grant ListP30 DK056341 / DK / NIDDK NIH HHS / United States
P30 DK056341-05S2 / DK / NIDDK NIH HHS / United States
P30 DK056341-06 / DK / NIDDK NIH HHS / United States