Obesity alters gut microbial ecology.

TitleObesity alters gut microbial ecology.
Publication TypeJournal Article
Year of Publication2005
AuthorsLey, RE, Bäckhed, F, Turnbaugh, P, Lozupone, CA, Knight, RD, Gordon, JI
JournalProc Natl Acad Sci U S A
Volume102
Issue31
Pagination11070-5
Date Published2005 Aug 2
ISSN0027-8424
KeywordsAnimals, Bacteria, Base Sequence, Cyanobacteria, DNA, Ecosystem, Female, Genes, Bacterial, Humans, Intestines, Mice, Mice, Inbred C57BL, Mice, Obese, Molecular Sequence Data, Obesity, Pregnancy, RNA, Ribosomal, 16S
Abstract

We have analyzed 5,088 bacterial 16S rRNA gene sequences from the distal intestinal (cecal) microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet. Although the majority of mouse gut species are unique, the mouse and human microbiota(s) are similar at the division (superkingdom) level, with Firmicutes and Bacteroidetes dominating. Microbial-community composition is inherited from mothers. However, compared with lean mice and regardless of kinship, ob/ob animals have a 50% reduction in the abundance of Bacteroidetes and a proportional increase in Firmicutes. These changes, which are division-wide, indicate that, in this model, obesity affects the diversity of the gut microbiota and suggest that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals. The sequences reported in this paper have been deposited in the GenBank database [accession nos. DQ 014552--DQ 015671 (mothers) and AY 989911--AY 993908 (offspring)].

DOI10.1073/pnas.0504978102
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID16033867
PubMed Central IDPMC1176910
Grant ListDK 007130 / DK / NIDDK NIH HHS / United States
DK 070977 / DK / NIDDK NIH HHS / United States