An obesity-associated gut microbiome with increased capacity for energy harvest.

TitleAn obesity-associated gut microbiome with increased capacity for energy harvest.
Publication TypeJournal Article
Year of Publication2006
AuthorsTurnbaugh, PJ, Ley, RE, Mahowald, MA, Magrini, V, Mardis, ER, Gordon, JI
JournalNature
Volume444
Issue7122
Pagination1027-31
Date Published2006 Dec 21
ISSN1476-4687
KeywordsAnimals, Bacteria, Cecum, Energy Metabolism, Genome, Bacterial, Mice, Mice, Inbred C57BL, Mice, Obese, Obesity, Sequence Analysis, DNA, Thinness
Abstract

The worldwide obesity epidemic is stimulating efforts to identify host and environmental factors that affect energy balance. Comparisons of the distal gut microbiota of genetically obese mice and their lean littermates, as well as those of obese and lean human volunteers have revealed that obesity is associated with changes in the relative abundance of the two dominant bacterial divisions, the Bacteroidetes and the Firmicutes. Here we demonstrate through metagenomic and biochemical analyses that these changes affect the metabolic potential of the mouse gut microbiota. Our results indicate that the obese microbiome has an increased capacity to harvest energy from the diet. Furthermore, this trait is transmissible: colonization of germ-free mice with an 'obese microbiota' results in a significantly greater increase in total body fat than colonization with a 'lean microbiota'. These results identify the gut microbiota as an additional contributing factor to the pathophysiology of obesity.

DOI10.1038/nature05414
Alternate JournalNature
PubMed ID17183312
Grant ListP30 DK056341 / DK / NIDDK NIH HHS / United States
P30 DK056341-05S2 / DK / NIDDK NIH HHS / United States
P30 DK056341-06 / DK / NIDDK NIH HHS / United States