Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21(st) International Symposium on Microsomes and Drug Oxidations (MDO).

TitleRegulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21(st) International Symposium on Microsomes and Drug Oxidations (MDO).
Publication TypeJournal Article
Year of Publication2017
AuthorsYu, A-M, Ingelman-Sundberg, M, Cherrington, NJ, Aleksunes, LM, Zanger, UM, Xie, W, Jeong, H, Morgan, EM, Turnbaugh, PJ, Klaassen, CD, Bhatt, AP, Redinbo, MR, Hao, P, Waxman, DJ, Wang, L, Zhong, X-B
JournalActa Pharm Sin B
Volume7
Issue2
Pagination241-248
Date Published2017 Mar
ISSN2211-3835
Abstract

Variations in drug metabolism may alter drug efficacy and cause toxicity; better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21(st) International Symposium on Microsomes and Drug Oxidations held in Davis, California, USA, in October 2-6, 2016, a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity, and discussed potential implications to personalized medications. A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption, distribution, metabolism, and excretion (ADME) and drug response. Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented. In addition, the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed. These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research.

DOI10.1016/j.apsb.2016.12.006
Alternate JournalActa Pharm Sin B
PubMed ID28388695
PubMed Central IDPMC5343155
Grant ListR01 ES019487 / ES / NIEHS NIH HHS / United States
R01 GM087376 / GM / NIGMS NIH HHS / United States
R01 GM118367 / GM / NIGMS NIH HHS / United States