2024
Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme.
Bae M, Le C, Mehta RS, Dong X, Pieper LM, Ramirez L, Alexander M, Kiamehr S, Turnbaugh PJ, Huttenhower C, Chan AT, Balskus EP.
Cell Host Microbe. 2024 Oct 28:S1931-3128(24)00360-3. doi: 10.1016/j.chom.2024.10.002. Online ahead of print. PMID: 39471822
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.
Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, Orellana D, Ang QY, Whitty C, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ.
Cell Rep. 2024 Oct 18:114891. doi: 10.1016/j.celrep.2024.114891. Online ahead of print. PMID: 39500329
Rationale and protocol for a safety, tolerability and feasibility randomized, parallel arm, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.
Stubbs BJ, Alvarez Azañedo G, Peralta S, Diaz SR, Gray W, Alexander L, Silverman-Martin W, Garcia TY, Blonquist TM, Upadhyay V, Turnbaugh PJ, Johnson JB, Newman JC.
PLoS One. 2024 Sep 18;19(9):e0307951. doi: 10.1371/journal.pone.0307951. eCollection 2024. PMID: 39292659
Pharma[e]cology: How the Gut Microbiome Contributes to Variations in Drug Response.
Trepka KR, Olson CA, Upadhyay V, Zhang C, Turnbaugh PJ.
Annu Rev Pharmacol Toxicol. 2024 Aug 6. doi: 10.1146/annurev-pharmtox-022724-100847. Online ahead of print. PMID: 39107044
Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice.
Tian Y, Rimal B, Bisanz JE, Gui W, Wolfe TM, Koo I, Murray IA, Nettleford SK, Yokoyama S, Dong F, Koshkin S, Prabhu KS, Turnbaugh PJ, Walk ST, Perdew GH, Patterson AD.
Environ Health Perspect. 2024 Aug;132(8):87005. doi: 10.1289/EHP13356. Epub 2024 Aug 14. PMID: 39140734
Effects of high dose aspartame-based sweetener on the gut microbiota and bone strength in young and aged mice.
Cyphert EL, Liu C, Morales AL, Nixon JC, Blackford E, Garcia M, Cevallos N, Turnbaugh PJ, Brito IL, Booth SL, Hernandez CJ.
JBMR Plus. 2024 Jun 18;8(8):ziae082. doi: 10.1093/jbmrpl/ziae082. eCollection 2024 Aug. PMID: 39011468
Digesting the complex metabolic effects of diet on the host and microbiome.
Carmody RN, Varady K, Turnbaugh PJ.
Cell. 2024 Jul 25;187(15):3857-3876. doi: 10.1016/j.cell.2024.06.032. PMID: 39059362
Emerging tools and best practices for studying gut microbial community metabolism.
Noecker C, Turnbaugh PJ.
Nat Metab. 2024 Jul 3. doi: 10.1038/s42255-024-01074-z. Online ahead of print. PMID: 38961185
Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors.
Kyaw TS, Zhang C, Sandy M, Trepka K, Zhang S, Ramirez Hernandez LA, Ramirez L, Goh JJN, Yu K, Dimassa V, Bess EN, Brockert JG, Dumlao DS, Bisanz JE, Turnbaugh PJ.
iScience. 2024 May 27;27(6):110122. doi: 10.1016/j.isci.2024.110122. eCollection 2024 Jun 21. PMID: 38947502
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.
McCurry MD, D'Agostino GD, Walsh JT, Bisanz JE, Zalosnik I, Dong X, Morris DJ, Korzenik JR, Edlow AG, Balskus EP, Turnbaugh PJ, Huh JR, Devlin AS.
Cell. 2024 May 21:S0092-8674(24)00514-2. doi: 10.1016/j.cell.2024.05.005. Online ahead of print. PMID: 38795705
High fat intake sustains sorbitol intolerance after antibiotic-mediated Clostridia depletion from the gut microbiota.
Lee JY, Tiffany CR, Mahan SP, Kellom M, Rogers AWL, Nguyen H, Stevens ET, Masson HLP, Yamazaki K, Marco ML, Eloe-Fadrosh EA, Turnbaugh PJ, Bäumler AJ.
Cell. 2024 Feb 29;187(5):1191-1205.e15. doi: 10.1016/j.cell.2024.01.029. Epub 2024 Feb 15.
2023
Simvastatin induces human gut bacterial cell surface genes.
Escalante V, Nayak RR, Noecker C, Babdor J, Spitzer M, Deutschbauer AM, Turnbaugh PJ.
Mol Microbiol. 2023 Sep 15. doi: 10.1111/mmi.15151. Online ahead of print. PMID: 37712143
Associations between the Gut Microbiota, Race, and Ethnicity of Patients with Colorectal Cancer: A Pilot and Feasibility Study.
Piawah S, Kyaw TS, Trepka K, Stewart AL, Mora RV, Stanfield D, Levine K, Van Blarigan EL, Venook A, Turnbaugh PJ, Nguyen T, Atreya CE.
Cancers. 2023 Sep 13;15(18):4546. doi: 10.3390/cancers15184546.
The global anaerobic metabolism regulator fnr is necessary for the degradation of food dyes and drugs by Escherichia coli.
Pieper LM, Spanogiannopoulos P, Volk RF, Miller CJ, Wright AT, Turnbaugh PJ.
mBio. 2023 Aug 29:e0157323. doi: 10.1128/mbio.01573-23. Online ahead of print. PMID: 37642463
Variety of fruit and vegetables and alcohol intake are associated with gut microbial species and gene abundance in colorectal cancer survivors.
Kyaw TS, Upadhyay V, Tolstykh I, Van Loon K, Laffan A, Stanfield D, Gempis D, Kenfield SA, Chan JM, Piawah S, Atreya CE, Ng K, Venook A, Kidder W, Turnbaugh PJ, Van Blarigan EL.
Am J Clin Nutr. 2023 Jul 18:S0002-9165(23)66055-1. doi: 10.1016/j.ajcnut.2023.07.011. Online ahead of print. PMID: 37474105
SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations.
Bustion AE, Nayak RR, Agrawal A, Turnbaugh PJ, Pollard KS.
eLife. 2023 Jun 12;12:e82401. doi: 10.7554/eLife.82401. Online ahead of print. PMID: 37306300
Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
Upadhyay V, Suryawanshi RK, Tasoff P, McCavitt-Malvido M, Kumar RG, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha CWY, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ.
mBio. 2023 Jun 9:e0088923. doi: 10.1128/mbio.00889-23. Online ahead of print. PMID: 37294090
Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta.
Noecker C, Sanchez J, Bisanz JE, Escalante V, Alexander M, Trepka K, Heinken A, Liu Y, Dodd D, Thiele I, DeFelice BC, Turnbaugh PJ.
PLoS Biol. 2023 May 19;21(5):e3002125. doi: 10.1371/journal.pbio.3002125. eCollection 2023 May. PMID: 37205710
Forging the microbiome to help us live long and prosper.
Rock RR, Turnbaugh PJ.
PLoS Biol. 2023 Apr 5;21(4):e3002087. doi: 10.1371/journal.pbio.3002087. eCollection 2023 Apr. PMID: 37018375
2022
Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators.
Dong X, Guthrie BGH, Alexander M, Noecker C, Ramirez L, Glasser NR, Turnbaugh PJ, Balskus EP.
Nat Commun. 2022 Dec 9;13(1):7624. doi: 10.1038/s41467-022-33576-3.
nicX-ing bad habits with your microbial friends.
Upadhyay V, Turnbaugh PJ.
Nat Metab. 2022 Nov;4(11):1442-1443. doi: 10.1038/s42255-022-00684-9.PMID: 36333489
Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.
Spanogiannopoulos P, Kyaw TS, Guthrie BGH, Bradley PH, Lee JV, Melamed J, Malig YNA, Lam KN, Gempis D, Sandy M, Kidder W, Van Blarigan EL, Atreya CE, Venook A, Gerona RR, Goga A, Pollard KS, Turnbaugh PJ.
Nat Microbiol. 2022 Oct;7(10):1605-1620. doi: 10.1038/s41564-022-01226-5. Epub 2022 Sep 22.
Tiny Gatekeepers: Microbial Control of Host Drug Transporters.
Kyaw TS, Turnbaugh PJ.
Clin Pharmacol Ther. 2022 Jun 6. doi: 10.1002/cpt.2647. Online ahead of print. PMID: 35668713
Designed secretion deters microbiome depletion.
Olson CA, Turnbaugh PJ.
Nat Microbiol. 2022 May 23. doi: 10.1038/s41564-022-01138-4. Online ahead of print. PMID: 35606423
Effects of caloric restriction on the gut microbiome are linked with immune senescence.
Sbierski-Kind J, Grenkowitz S, Schlickeiser S, Sandforth A, Friedrich M, Kunkel D, Glauben R, Brachs S, Mai K, Thürmer A, Radonić A, Drechsel O, Turnbaugh PJ, Bisanz JE, Volk HD, Spranger J, von Schwartzenberg RJ.
Microbiome. 2022 Apr 4;10(1):57. doi: 10.1186/s40168-022-01249-4.
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites.
Paik D, Yao L, Zhang Y, Bae S, D'Agostino GD, Zhang M, Kim E, Franzosa EA, Avila-Pacheco J, Bisanz JE, Rakowski CK, Vlamakis H, Xavier RJ, Turnbaugh PJ, Longman RS, Krout MR, Clish CB, Rastinejad F, Huttenhower C, Huh JR, Devlin AS.
Nature. 2022 Mar;603(7903):907-912. doi: 10.1038/s41586-022-04480-z. Epub 2022 Mar 16.
Synthetic glycans control gut microbiome structure and mitigate colitis in mice.
Tolonen AC, Beauchemin N, Bayne C, Li L, Tan J, Lee J, Meehan BM, Meisner J, Millet Y, LeBlanc G, Kottler R, Rapp E, Murphy C, Turnbaugh PJ, von Maltzahn G, Liu CM, van Hylckama Vlieg JET.
Nat Commun. 2022 Mar 10;13(1):1244. doi: 10.1038/s41467-022-28856-x.
Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.
Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG.
J Clin Invest. 2022 Jan 25:e154993. doi: 10.1172/JCI154993. Online ahead of print.
Human gut bacterial metabolism drives Th17 activation and colitis.
Alexander M, Ang QY, Nayak RR, Bustion AE, Sandy M, Zhang B, Upadhyay V, Pollard KS, Lynch SV, Turnbaugh PJ.
Cell Host Microbe. 2022 Jan 12;30(1):17-30.e9. doi: 10.1016/j.chom.2021.11.001. Epub 2021 Nov 24.
2021
Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome.
Lam KN, Spanogiannopoulos P, Soto-Perez P, Alexander M, Nalley MJ, Bisanz JE, Nayak RR, Weakley AM, Yu FB, Turnbaugh PJ.
Cell Rep. 2021 Nov 2;37(5):109930. doi: 10.1016/j.celrep.2021.109930.
The East Asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health.
Ang QY, Alba DL, Upadhyay V, Bisanz JE, Cai J, Lee HL, Barajas E, Wei G, Noecker C, Patterson AD, Koliwad SK, Turnbaugh PJ.
eLife. 2021 Oct 7;10:e70349. doi: 10.7554/eLife.70349.
Caloric restriction disrupts the microbiota and colonization resistance.
von Schwartzenberg RJ, Bisanz JE, Lyalina S, Spanogiannopoulos P, Ang QY, Cai J, Dickmann S, Friedrich M, Liu SY, Collins SL, Ingebrigtsen D, Miller S, Turnbaugh JA, Patterson AD, Pollard KS, Mai K, Spranger J, Turnbaugh PJ.
Nature. 2021 Jul;595(7866):272-277. doi: 10.1038/s41586-021-03663-4. Epub 2021 Jun 23.
The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis.
Artacho A, Isaac S, Nayak R, Flor-Duro A, Alexander M, Koo I, Manasson J, Smith PB, Rosenthal P, Homsi Y, Gulko P, Pons J, Puchades-Carrasco L, Izmirly P, Patterson A, Abramson SB, Pineda-Lucena A, Turnbaugh PJ, Ubeda C, Scher JU.
Arthritis Rheumatol. 2021 Jun;73(6):931-942. doi: 10.1002/art.41622. Epub 2021 May 2.
Dissecting the contribution of host genetics and the microbiome in complex behaviors.
Buffington SA, Dooling SW, Sgritta M, Noecker C, Murillo OD, Felice DF, Turnbaugh PJ, Costa-Mattioli M.
Cell. 2021 Apr 1;184(7):1740-1756.e16. doi: 10.1016/j.cell.2021.02.009. Epub 2021 Mar 10.
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.
Nayak RR, Alexander M, Deshpande I, Stapleton-Gray K, Rimal B, Patterson AD, Ubeda C, Scher JU, Turnbaugh PJ.
Cell Host Microbe. 2021 Mar 10;29(3):362-377.e11. doi: 10.1016/j.chom.2020.12.008. Epub 2021 Jan 12.
Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments.
Liu H, Shiver AL, Price MN, Carlson HK, Trotter VV, Chen Y, Escalante V, Ray J, Hern KE, Petzold CJ, Turnbaugh PJ, Huang KC, Arkin AP, Deutschbauer AM.
Cell Rep. 2021 Mar 2;34(9):108789. doi: 10.1016/j.celrep.2021.108789.PMID: 33657378
2020
Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections.
Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC.
Med (N Y). 2020 Dec 18;1(1):43-65. doi: 10.1016/j.medj.2020.06.008. Epub 2020 Jul 15.
A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.
Man K, Bowman C, Braverman KN, Escalante V, Tian Y, Bisanz JE, Ganeshan K, Wang B, Patterson A, Bayrer JR, Turnbaugh PJ, Chawla A.
Proc Natl Acad Sci U S A. 2020 Nov 30:202012003. doi: 10.1073/pnas.2012003117. Online ahead of print.
Gut microbiota-specific IgA+ B cells traffic to the CNS in active multiple sclerosis.
Pröbstel AK, Zhou X, Baumann R, Wischnewski S, Kutza M, Rojas OL, Sellrie K, Bischof A, Kim K, Ramesh A, Dandekar R, Greenfield AL, Schubert RD, Bisanz JE, Vistnes S, Khaleghi K, Landefeld J, Kirkish G, Liesche-Starnecker F, Ramaglia V, Singh S, Tran EB, Barba P, Zorn K, Oechtering J, Forsberg K, Shiow LR, Henry RG, Graves J, Cree BAC, Hauser SL, Kuhle J, Gelfand JM, Andersen PM, Schlegel J, Turnbaugh PJ, Seeberger PH, Gommerman JL, Wilson MR, Schirmer L, Baranzini SE.
Sci Immunol. 2020 Nov 20;5(53):eabc7191. doi: 10.1126/sciimmunol.abc7191.
Stressed-out gut bacteria are pterin up gut inflammation.
Alexander M, Turnbaugh PJ.
Nat Microbiol. 2020 Nov;5(11):1316-1318. doi: 10.1038/s41564-020-00804-9.
Deconstructing Mechanisms of Diet-Microbiome-Immune Interactions.
Alexander M, Turnbaugh PJ.
Immunity. 2020 Aug 18;53(2):264-276. doi: 10.1016/j.immuni.2020.07.015.
Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.
Zou L, Spanogiannopoulos P, Pieper LM, Chien HC, Cai W, Khuri N, Pottel J, Vora B, Ni Z, Tsakalozou E, Zhang W, Shoichet BK, Giacomini KM, Turnbaugh PJ.
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018. doi: 10.1073/pnas.1920483117. Epub 2020 Jun 22.
Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells.
Ang QY, Alexander M, Newman JC, Tian Y, Cai J, Upadhyay V, Turnbaugh JA, Verdin E, Hall KD, Leibel RL, Ravussin E, Rosenbaum M, Patterson AD, Turnbaugh PJ.
Cell. 2020 Jun 11;181(6):1263-1275.e16. doi: 10.1016/j.cell.2020.04.027. Epub 2020 May 20.
A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria.
Bisanz JE, Soto-Perez P, Noecker C, Aksenov AA, Lam KN, Kenney GE, Bess EN, Haiser HJ, Kyaw TS, Yu FB, Rekdal VM, Ha CWY, Devkota S, Balskus EP, Dorrestein PC, Allen-Vercoe E, Turnbaugh PJ.
Cell Host Microbe. 2020 Jun 10;27(6):1001-1013.e9. doi: 10.1016/j.chom.2020.04.006. Epub 2020
Probing the tumor micro(b)environment.
Atreya CE, Turnbaugh PJ.
Science. 2020 May 29;368(6494):938-939. doi: 10.1126/science.abc1464.PMID: 32467376
Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response.
Scher JU, Nayak RR, Ubeda C, Turnbaugh PJ, Abramson SB.
Nat Rev Rheumatol. 2020 May;16(5):282-292. doi: 10.1038/s41584-020-0395-3. Epub 2020 Mar 10.
Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans.
Basolo A, Hohenadel M, Ang QY, Piaggi P, Heinitz S, Walter M, Walter P, Parrington S, Trinidad DD, von Schwartzenberg RJ, Turnbaugh PJ, Krakoff J.
Nat Med. 2020 Apr;26(4):589-598. doi: 10.1038/s41591-020-0801-z. Epub 2020 Mar 23.
Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation.
Razani B, Whang MI, Kim FS, Nakamura MC, Sun X, Advincula R, Turnbaugh JA, Pendse M, Tanbun P, Achacoso P, Turnbaugh PJ, Malynn BA, Ma A.
Nat Immunol. 2020 Apr;21(4):422-433. doi: 10.1038/s41590-020-0634-4. Epub 2020 Mar 16.
Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers.
Parker MFL, Luu JM, Schulte B, Huynh TL, Stewart MN, Sriram R, Yu MA, Jivan S, Turnbaugh PJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM.
ACS Cent Sci. 2020 Feb 26;6(2):155-165. doi: 10.1021/acscentsci.9b00743. Epub 2020 Feb 4.
A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols.
Maini Rekdal V, Nol Bernadino P, Luescher MU, Kiamehr S, Le C, Bisanz JE, Turnbaugh PJ, Bess EN, Balskus EP.
eLife. 2020 Feb 18;9. pii: e50845. doi: 10.7554/eLife.50845.
Diet should be a tool for researchers, not a treatment.
Turnbaugh PJ.
Nature. 2020 Jan;577(7792):S23. doi: 10.1038/d41586-020-00202-5.
Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria.
Bess EN, Bisanz JE, Yarza F, Bustion A, Rich BE, Li X, Kitamura S, Waligurski E, Ang QY, Alba DL, Spanogiannopoulos P, Nayfach S, Koliwad SK, Wolan DW, Franke AA, Turnbaugh PJ.
Nat Microbiol. 2020 Jan;5(1):56-66. doi: 10.1038/s41564-019-0596-1. Epub 2019 Nov 4.
2019
Cooking shapes the structure and function of the gut microbiome
Carmody RN, Bisanz JE, Bowen BP, Maurice CF, Lyalina S, Louie KB, Treen D, Chadaideh KS, Maini Rekdal V, Bess EN, Spanogiannopoulos P, Ang QY, Bauer KC, Balon TW, Pollard KS, Northen TR, Turnbaugh PJ.
Nat Microbiol. 2019 Dec;4(12):2052-2063. doi: 10.1038/s41564-019-0569-4. Epub 2019 Sep 30.
Using DNA Metabarcoding To Evaluate the Plant Component of Human Diets: a Proof of Concept.
Reese AT, Kartzinel TR, Petrone BL, Turnbaugh PJ, Pringle RM, David LA.
mSystems. 2019 Oct 8;4(5). pii: e00458-19. doi: 10.1128/mSystems.00458-19.
CRISPR-Cas System of a Prevalent Human Gut Bacterium Reveals Hyper-targeting against Phages in a Human Virome Catalog
Soto-Perez P, Bisanz JE, Berry JD, Lam KN, Bondy-Denomy J, Turnbaugh PJ.
Cell Host Microbe. 2019 Sep 11;26(3):325-335.e5. doi: 10.1016/j.chom.2019.08.008.
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, Alexander H, Alm EJ, Arumugam M, Asnicar F, Bai Y, Bisanz JE, Bittinger K, Brejnrod A, Brislawn CJ, Brown CT, Callahan BJ, Caraballo-Rodríguez AM, Chase J, Cope EK, Da Silva R, Diener C, Dorrestein PC, Douglas GM, Durall DM, Duvallet C, Edwardson CF, Ernst M, Estaki M, Fouquier J, Gauglitz JM, Gibbons SM, Gibson DL, Gonzalez A, Gorlick K, Guo J, Hillmann B, Holmes S, Holste H, Huttenhower C, Huttley GA, Janssen S, Jarmusch AK, Jiang L, Kaehler BD, Kang KB, Keefe CR, Keim P, Kelley ST, Knights D, Koester I, Kosciolek T, Kreps J, Langille MGI, Lee J, Ley R, Liu YX, Loftfield E, Lozupone C, Maher M, Marotz C, Martin BD, McDonald D, McIver LJ, Melnik AV, Metcalf JL, Morgan SC, Morton JT, Naimey AT, Navas-Molina JA, Nothias LF, Orchanian SB, Pearson T, Peoples SL, Petras D, Preuss ML, Pruesse E, Rasmussen LB, Rivers A, Robeson MS 2nd, Rosenthal P, Segata N, Shaffer M, Shiffer A, Sinha R, Song SJ, Spear JR, Swafford AD, Thompson LR, Torres PJ, Trinh P, Tripathi A, Turnbaugh PJ, Ul-Hasan S, van der Hooft JJJ, Vargas F, Vázquez-Baeza Y, Vogtmann E, von Hippel M, Walters W, Wan Y, Wang M, Warren J, Weber KC, Williamson CHD, Willis AD, Xu ZZ, Zaneveld JR, Zhang Y, Zhu Q, Knight R, Caporaso JG.
Nat Biotechnol. 2019 Jul 24. doi: 10.1038/s41587-019-0209-9. [Epub ahead of print]
Meta-analysis reveals reproducible gut microbiome alterations in response to a high-fat diet
Bisanz JE, Upadhyay V, Turnbaugh JA, Ly K, Turnbaugh PJ.
Cell Host Microbe. 2019 Jul 12. pii: S1931-3128(19)30302-6. doi: 10.1016/j.chom.2019.06.013. [Epub ahead of print]
Precision medicine goes microscopic: engineering the microbiome to improve drug outcomes
Lam KN, Alexander M, Turnbaugh PJ.
Cell Host Microbe. 2019 Jul 10;26(1):22-34. doi: 10.1016/j.chom.2019.06.011.
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Maini Rekdal V, Bess EN, Bisanz JE, Turnbaugh PJ, Balskus EP.
Science. 2019 Jun 14;364(6445). pii: eaau6323. doi: 10.1126/science.aau6323.
Nutrient sensing in CD11c cells alters the gut microbiota to regulate food intake and body mass
Chagwedera DN, Ang QY, Bisanz JE, Leong YA, Ganeshan K, Cai J, Patterson AD, Turnbaugh PJ, Chawla A.
Cell Metab. 2019 May 21. pii: S1550-4131(19)30242-6. doi: 10.1016/j.cmet.2019.05.002.
Megaphages infect Prevotella and variants are widespread in gut microbiomes
Devoto, AE, Santini, JM, Olm, MR, Anantharaman, K, Munk, P, Tung, J, Archie, EA, Turnbaugh, PJ, Seed, KD, Blekhman, R, Aarestrup, FM, Thomas, BC, Banfield, JF
Nat Microbiol. 2019 Apr;4(4):693-700. doi: 10.1038/s41564-018-0338-9. Epub 2019 Jan 28.
2018
Announcement of 2019 Keystone Symposia Conference: "Microbiome: Chemical Mechanisms and Biological Consequences"
Balskus, EP, Turnbaugh, PJ, Wolan, DW
mSystems. 2018 Jul 24;3(4). pii: e00115-18. doi: 10.1128/mSystems.00115-18. eCollection 2018 Jul-Aug.
Broad collateral damage of drugs against the gut microbiome
Spanogiannopoulos, P, Turnbaugh, PJ
Nat Rev Gastroenterol Hepatol. 2018 Aug;15(8):457-458. doi: 10.1038/s41575-018-0028-3.
Chemical reaction vector embeddings: towards predicting drug metabolism in the human gut microbiome
Mallory, EK, Acharya, A, Rensi, SE, Turnbaugh, PJ, Bright, RA, Altman, RB
Pac Symp Biocomput. 2018;23:56-67.
Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling
Fuks, G, Elgart, M, Amir, A, Zeisel, A, Turnbaugh, PJ, Soen, Y, Shental, N
Microbiome. 2018 Jan 26;6(1):17. doi: 10.1186/s40168-017-0396-x.
Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins
Koppel, N, Bisanz, JE, Pandelia, M-E, Turnbaugh, PJ, Balskus, EP
Elife. 2018 May 15;7. pii: e33953. doi: 10.7554/eLife.33953.
Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health
Zhang, L, Carmody, RN, Kalariya, HM, Duran, RM, Moskal, K, Poulev, A, Kuhn, P, Tveter, KM, Turnbaugh, PJ, Raskin, I, Roopchand, DE
J Nutr Biochem. 2018 Jun;56:142-151. doi: 10.1016/j.jnutbio.2018.02.009. Epub 2018 Feb 15.
How to determine the role of the microbiome in drug disposition
Bisanz, JE, Spanogiannopoulos, P, Pieper, LM, Bustion, AE, Turnbaugh, PJ
Drug Metab Dispos. 2018 Nov;46(11):1588-1595. doi: 10.1124/dmd.118.083402. Epub 2018 Aug 15.
Making millennial medicine more meta
Turnbaugh, PJ
mSystems. 2018 Mar 6;3(2). pii: e00154-17. doi: 10.1128/mSystems.00154-17. eCollection 2018 Mar-Apr.
A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling
Schneider, C, O'Leary, CE, von Moltke, J, Liang, H-E, Ang, QYan, Turnbaugh, PJ, Radhakrishnan, S, Pellizzon, M, Ma, A, Locksley, RM
Cell. 2018 Jul 12;174(2):271-284.e14. doi: 10.1016/j.cell.2018.05.014. Epub 2018 Jun 7.
Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories
Stanhope, KL, Goran, MI, Bosy-Westphal, A, King, JC, Schmidt, LA, Schwarz, J-M, Stice, E, Sylvetsky, AC, Turnbaugh, PJ, Bray, GA, Gardner, CD, Havel, PJ, Malik, V, Mason, AE, Ravussin, E, Rosenbaum, M, Welsh, JA, Allister-Price, C, Sigala, DM, Greenwood, MRC, Astrup, A, Krauss, RM
Obes Rev. 2018 Sep;19(9):1205-1235. doi: 10.1111/obr.12699. Epub 2018 May 14.
2017
Assessment of variation in microbial community amplicon sequencing by the Microbiome Quality Control (MBQC) project consortium.
Sinha R, Abu-Ali G, Vogtmann E, Fodor AA, Ren B, Amir A, Schwager E, Crabtree J, Ma S; Microbiome Quality Control Project Consortium, Abnet CC, Knight R, White O, Huttenhower C.
Nat Biotechnol. 2017 Nov;35(11):1077-1086. doi: 10.1038/nbt.3981. Epub 2017 Oct 2.
Microbes and diet-induced obesity: fast, cheap, and out of control
Turnbaugh, PJ
Cell Host Microbe. 2017 Mar 8;21(3):278-281. doi: 10.1016/j.chom.2017.02.021.
Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21(st) International Symposium on Microsomes and Drug Oxidations (MDO)
Yu, A-M, Ingelman-Sundberg, M, Cherrington, NJ, Aleksunes, LM, Zanger, UM, Xie, W, Jeong, H, Morgan, EM, Turnbaugh, PJ, Klaassen, CD, Bhatt, AP, Redinbo, MR, Hao, P, Waxman, DJ, Wang, L, Zhong, X-B
Acta Pharm Sin B. 2017 Mar;7(2):241-248. doi: 10.1016/j.apsb.2016.12.006. Epub 2017 Feb 1.
2016
The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism
Spanogiannopoulos, P, Bess, EN, Carmody, RN, Turnbaugh, PJ
Nat Rev Microbiol. 2016 Apr;14(5):273-87. doi: 10.1038/nrmicro.2016.17. Epub 2016 Mar 14.
Mirror, mirror on the wall: which microbiomes will help heal them all?
Nayak, RR, Turnbaugh, PJ
BMC Med. 2016 May 4;14:72. doi: 10.1186/s12916-016-0622-6.
mockrobiota: a Public Resource for Microbiome Bioinformatics Benchmarking
Bokulich, NA, Rideout, JRam, Mercurio, WG, Shiffer, A, Wolfe, B, Maurice, CF, Dutton, RJ, Turnbaugh, PJ, Knight, R, J Caporaso, G
mSystems. 2016 Oct 18;1(5). pii: e00062-16. eCollection 2016 Sep-Oct.
2015
Characterization and detection of a widely distributed gene cluster that predicts anaerobic choline utilization by human gut bacteria
del Campo, AMartínez-, Bodea, S, Hamer, HA, Marks, JA, Haiser, HJ, Turnbaugh, PJ, Balskus, EP
MBio. 2015 Apr 14;6(2). pii: e00042-15. doi: 10.1128/mBio.00042-15.
Diet dominates host genotype in shaping the murine gut microbiota.
Carmody, RN, Gerber, GK, Luevano, JM, Gatti, DM, Somes, L, Svenson, KL, Turnbaugh, PJ
Cell Host Microbe. 2015 Jan 14;17(1):72-84. doi: 10.1016/j.chom.2014.11.010. Epub 2014 Dec 18.
Dietary polyphenols promote growth of the gut bacterium Akkermansia muciniphila and attenuate high-fat diet-induced metabolic syndrome
Roopchand, DE, Carmody, RN, Kuhn, P, Moskal, K, Rojas-Silva, P, Turnbaugh, PJ, Raskin, I
Diabetes. 2015 Aug;64(8):2847-58. doi: 10.2337/db14-1916. Epub 2015 Apr 6.
Functional characterization of bacteria isolated from ancient arctic soil exposes diverse resistance mechanisms to modern antibiotics
Perron, GG, Whyte, L, Turnbaugh, PJ, Goordial, J, Hanage, WP, Dantas, G, Desai, MM
PLoS One. 2015 Mar 25;10(3):e0069533. doi: 10.1371/journal.pone.0069533. eCollection 2015.
Gut microbial succession follows acute secretory diarrhea in humans
David, LA, Weil, A, Ryan, ET, Calderwood, SB, Harris, JB, Chowdhury, F, Begum, Y, Qadri, F, LaRocque, RC, Turnbaugh, PJ
MBio. 2015 May 19;6(3):e00381-15. doi: 10.1128/mBio.00381-15.
Marked seasonal variation in the wild mouse gut microbiota
Maurice, CF, Knowles, SCL, Ladau, J, Pollard, KS, Fenton, A, Pedersen, AB, Turnbaugh, PJ
ISME J. 2015 Nov;9(11):2423-34. doi: 10.1038/ismej.2015.53. Epub 2015 May 29.
Siri, What Should I Eat?
von Schwartzenberg, RJumpertz, Turnbaugh, PJ
Cell. 2015 Nov 19;163(5):1051-1052. doi: 10.1016/j.cell.2015.11.012.
2014
Diet rapidly and reproducibly alters the human gut microbiome
David, LA, Maurice, CF, Carmody, RN, Gootenberg, DB, Button, JE, Wolfe, BE, Ling, AV, A Devlin, S, Varma, Y, Fischbach, MA, Biddinger, SB, Dutton, RJ, Turnbaugh, PJ
Nature. 2014 Jan 23;505(7484):559-63. doi: 10.1038/nature12820. Epub 2013 Dec 11.
Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics.
Carmody, RN, Turnbaugh, PJ
J Clin Invest. 2014 Oct;124(10):4173-81. doi: 10.1172/JCI72335. Epub 2014 Aug 8.
The intestinal metabolome: an intersection between microbiota and host
Ursell, LK, Haiser, HJ, Van Treuren, W, Garg, N, Reddivari, L, Vanamala, J, Dorrestein, PC, Turnbaugh, PJ, Knight, R
Gastroenterology. 2014 May;146(6):1470-6. doi: 10.1053/j.gastro.2014.03.001. Epub 2014 Mar 11.
Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics
Haiser, HJ, Seim, KL, Balskus, EP, Turnbaugh, PJ
Gut Microbes. 2014 Mar-Apr;5(2):233-8. doi: 10.4161/gmic.27915. Epub 2014 Jan 23.
Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology
Patterson, AD, Turnbaugh, PJ
Cell Metab. 2014 Nov 4;20(5):761-768. doi: 10.1016/j.cmet.2014.07.002. Epub 2014 Aug 21.
Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness
Pickard, JM, Maurice, CF, Kinnebrew, MA, Abt, MC, Schenten, D, Golovkina, TV, Bogatyrev, SR, Ismagilov, RF, Pamer, EG, Turnbaugh, PJ, Chervonsky, AV
Nature. 2014 Oct 30;514(7524):638-41. doi: 10.1038/nature13823. Epub 2014 Oct 1.
2013
Cancer: An acidic link
Devkota, S, Turnbaugh, PJ
Nature. 2013 Jul 4;499(7456):37-8. doi: 10.1038/nature12404. Epub 2013 Jun 26.
Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity
Liou, AP, Paziuk, M, Luevano, J-M, Machineni, S, Turnbaugh, PJ, Kaplan, LM
Sci Transl Med. 2013 Mar 27;5(178):178ra41. doi: 10.1126/scitranslmed.3005687.
Developing a metagenomic view of xenobiotic metabolism
Haiser, HJ, Turnbaugh, PJ
Pharmacol Res. 2013 Mar;69(1):21-31. doi: 10.1016/j.phrs.2012.07.009. Epub 2012 Aug 9.
High-resolution microbial community reconstruction by integrating short reads from multiple 16S rRNA regions
Amir, A, Zeisel, A, Zuk, O, Elgart, M, Stern, S, Shamir, O, Turnbaugh, PJ, Soen, Y, Shental, N
Nucleic Acids Res. 2013 Dec;41(22):e205. doi: 10.1093/nar/gkt1070. Epub 2013 Nov 7.
Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta
Haiser, HJ, Gootenberg, DB, Chatman, K, Sirasani, G, Balskus, EP, Turnbaugh, PJ
Science. 2013 Jul 19;341(6143):295-8. doi: 10.1126/science.1235872.
Quantifying and identifying the active and damaged subsets of indigenous microbial communities
Maurice, CFerrier, Turnbaugh, PJames
Methods Enzymol. 2013;531:91-107. doi: 10.1016/B978-0-12-407863-5.00005-8.
Quantifying the metabolic activities of human-associated microbial communities across multiple ecological scales
Maurice, CF, Turnbaugh, PJ
FEMS Microbiol Rev. 2013 Sep;37(5):830-48. doi: 10.1111/1574-6976.12022. Epub 2013 Apr 22.
Translating the human microbiome
Brown, J, de Vos, WM, DiStefano, PS, Doré, J, Huttenhower, C, Knight, R, Lawley, TD, Raes, J, Turnbaugh, P
Nat Biotechnol. 2013 Apr;31(4):304-8. doi: 10.1038/nbt.2543.
Xenobiotics shape the physiology and gene expression of the active human gut microbiome.
Maurice CF, Haiser HJ, Turnbaugh PJ.
Cell. 2013 Jan 17;152(1-2):39-50. doi: 10.1016/j.cell.2012.10.052.PMID: 23332745
2012
Antibiotic exposure promotes fat gain
Liou, AP, Turnbaugh, PJ
Cell Metab. 2012 Oct 3;16(4):408-10. doi: 10.1016/j.cmet.2012.09.009.
Gut microbes make for fattier fish
Carmody, RN, Turnbaugh, PJ
Cell Host Microbe. 2012 Sep 13;12(3):259-61. doi: 10.1016/j.chom.2012.08.006.
Is it time for a metagenomic basis of therapeutics?
Haiser, HJ, Turnbaugh, PJ
Science. 2012 Jun 8;336(6086):1253-5. doi: 10.1126/science.1224396. Epub 2012 Jun 6.
Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease
Greenblum, S, Turnbaugh, PJ, Borenstein, E
Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):594-9. doi: 10.1073/pnas.1116053109. Epub 2011 Dec 19.
Microbiology: fat, bile and gut microbes
Turnbaugh, PJ
Nature. 2012 Jul 4;487(7405):47-8. doi: 10.1038/487047a.
Taking a metagenomic view of human nutrition
Dutton, RJ, Turnbaugh, PJ
Curr Opin Clin Nutr Metab Care. 2012 Sep;15(5):448-54. doi: 10.1097/MCO.0b013e3283561133.
2011
Companion animals symposium: humanized animal models of the microbiome
Gootenberg, DB, Turnbaugh, PJ
J Anim Sci. 2011 May;89(5):1531-7. doi: 10.2527/jas.2010-3371. Epub 2010 Sep 10.
Companion animals symposium: microbes and health
Swanson, KS, Suchodolski, JS, Turnbaugh, PJ
J Anim Sci. 2011 May;89(5):1496-7. doi: 10.2527/jas.2011-3873.
Detecting novel associations in large data sets
Reshef, DN, Reshef, YA, Finucane, HK, Grossman, SR, McVean, G, Turnbaugh, PJ, Lander, ES, Mitzenmacher, M, Sabeti, PC
Science. 2011 Dec 16;334(6062):1518-24. doi: 10.1126/science.1205438.
Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans
Jumpertz, R, Le, DSon, Turnbaugh, PJ, Trinidad, C, Bogardus, C, Gordon, JI, Krakoff, J
Am J Clin Nutr. 2011 Jul;94(1):58-65. doi: 10.3945/ajcn.110.010132. Epub 2011 May 4.
Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample
J Caporaso, G, Lauber, CL, Walters, WA, Berg-Lyons, D, Lozupone, CA, Turnbaugh, PJ, Fierer, N, Knight, R
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4516-22. doi: 10.1073/pnas.1000080107. Epub 2010 Jun 3.
Human health and disease in a microbial world
Turnbaugh, PJ, Stintzi, A
Front Microbiol. 2011 Sep 16;2:190. doi: 10.3389/fmicb.2011.00190. eCollection 2011.
The mind-body-microbial continuum
Gonzalez, A, Stombaugh, J, Lozupone, C, Turnbaugh, PJ, Gordon, JI, Knight, R
Dialogues Clin Neurosci. 2011;13(1):55-62.
Removing noise from pyrosequenced amplicons.
Quince, C, Lanzen, A, Davenport, RJ, Turnbaugh, PJ
BMC Bioinformatics. 2011 Jan 28;12:38. doi: 10.1186/1471-2105-12-38.
Taxonomic metagenome sequence assignment with structured output models
Patil, KR, Haider, P, Pope, PB, Turnbaugh, PJ, Morrison, M, Scheffer, T, McHardy, AC
Nat Methods. 2011 Mar;8(3):191-2. doi: 10.1038/nmeth0311-191.
Wild immunology: converging on the real world
Babayan, SA, Allen, JE, Bradley, JE, Geuking, MB, Graham, AL, Grencis, RK, Kaufman, J, McCoy, KD, Paterson, S, Smith, KGC, Turnbaugh, PJ, Viney, ME, Maizels, RM, Pedersen, AB
Ann N Y Acad Sci. 2011 Oct;1236:17-29. doi: 10.1111/j.1749-6632.2011.06251.x.
2010
A microbe-dependent viral key to Crohn's box
Peterson, DA, Turnbaugh, PJ
Sci Transl Med. 2010 Aug 4;2(43):43ps39. doi: 10.1126/scitranslmed.3001422.
Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins
Turnbaugh, PJ, Quince, C, Faith, JJ, McHardy, AC, Yatsunenko, T, Niazi, F, Affourtit, J, Egholm, M, Henrissat, B, Knight, R, Gordon, JI
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7503-8. doi: 10.1073/pnas.1002355107. Epub 2010 Apr 2.
QIIME allows analysis of high-throughput community sequencing data
J Caporaso, G, Kuczynski, J, Stombaugh, J, Bittinger, K, Bushman, FD, Costello, EK, Fierer, N, Peña, AGonzalez, Goodrich, JK, Gordon, JI, Huttley, GA, Kelley, ST, Knights, D, Koenig, JE, Ley, RE, Lozupone, CA, McDonald, D, Muegge, BD, Pirrung, M, Reeder, J, Sevinsky, JR, Turnbaugh, PJ, Walters, WA, Widmann, J, Yatsunenko, T, Zaneveld, J, Knight, R
Nat Methods. 2010 May;7(5):335-6. doi: 10.1038/nmeth.f.303. Epub 2010 Apr 11.
Viewing the human microbiome through three-dimensional glasses: integrating structural and functional studies to better define the properties of myriad carbohydrate-active enzymes
Turnbaugh, PJ, Henrissat, B, Gordon, JI
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1261-4. doi: 10.1107/S1744309110029088. Epub 2010 Jul 31.
2009
Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla
Mahowald, MA, Rey, FE, Seedorf, H, Turnbaugh, PJ, Fulton, RS, Wollam, A, Shah, N, Wang, C, Magrini, V, Wilson, RK, Cantarel, BL, Coutinho, PM, Henrissat, B, Crock, LW, Russell, A, Verberkmoes, NC, Hettich, RL, Gordon, JI
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5859-64. doi: 10.1073/pnas.0901529106. Epub 2009 Mar 24.
The core gut microbiome, energy balance and obesity
Turnbaugh, PJ, Gordon, JI
J Physiol. 2009 Sep 1;587(Pt 17):4153-8. doi: 10.1113/jphysiol.2009.174136. Epub 2009 Jun 2.
A core gut microbiome in obese and lean twins
Turnbaugh, PJ, Hamady, M, Yatsunenko, T, Cantarel, BL, Duncan, A, Ley, RE, Sogin, ML, Jones, WJ, Roe, BA, Affourtit, JP, Egholm, M, Henrissat, B, Heath, AC, Knight, R, Gordon, JI
Nature. 2009 Jan 22;457(7228):480-4. doi: 10.1038/nature07540. Epub 2008 Nov 30.
2008
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
Turnbaugh, PJ, Bäckhed, F, Fulton, L, Gordon, JI
Cell Host Microbe. 2008 Apr 17;3(4):213-23. doi: 10.1016/j.chom.2008.02.015.
Evolution of mammals and their gut microbes
Ley, RE, Hamady, M, Lozupone, C, Turnbaugh, PJ, Ramey, RRoy, J Bircher, S, Schlegel, ML, Tucker, TA, Schrenzel, MD, Knight, R, Gordon, JI
Science. 2008 Jun 20;320(5883):1647-51. doi: 10.1126/science.1155725. Epub 2008 May 22.
Host-bacterial coevolution and the search for new drug targets
Zaneveld, J, Turnbaugh, PJ, Lozupone, C, Ley, RE, Hamady, M, Gordon, JI, Knight, R
Curr Opin Chem Biol. 2008 Feb;12(1):109-14. doi: 10.1016/j.cbpa.2008.01.015. Epub 2008 Mar 5.
An invitation to the marriage of metagenomics and metabolomics
Turnbaugh, PJ, Gordon, JI
Cell. 2008 Sep 5;134(5):708-13. doi: 10.1016/j.cell.2008.08.025.
2007
The human microbiome project
Turnbaugh, PJ, Ley, RE, Hamady, M, Fraser-Liggett, CM, Knight, R, Gordon, JI
Nature. 2007 Oct 18;449(7164):804-10.
2006
Metagenomic analysis of the human distal gut microbiome
Gill, SR, Pop, M, Deboy, RT, Eckburg, PB, Turnbaugh, PJ, Samuel, BS, Gordon, JI, Relman, DA, Fraser-Liggett, CM, Nelson, KE
Science. 2006 Jun 2;312(5778):1355-9.
Microbial ecology: human gut microbes associated with obesity
Ley, RE, Turnbaugh, PJ, Klein, S, Gordon, JI
Nature. 2006 Dec 21;444(7122):1022-3.
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, PJ, Ley, RE, Mahowald, MA, Magrini, V, Mardis, ER, Gordon, JI
Nature. 2006 Dec 21;444(7122):1027-31.
2005
Discovery, validation, and genetic dissection of transcription factor binding sites by comparative and functional genomics
Gertz, J, Riles, L, Turnbaugh, P, Ho, S-W, Cohen, BA
Genome Res. 2005 Aug;15(8):1145-52.
Obesity alters gut microbial ecology
Ley, RE, Bäckhed, F, Turnbaugh, P, Lozupone, CA, Knight, RD, Gordon, JI
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5. Epub 2005 Jul 20.